{"id":2913,"date":"2022-01-07T15:35:00","date_gmt":"2022-01-07T07:35:00","guid":{"rendered":"https:\/\/o2genes.com\/?p=2913"},"modified":"2023-11-25T16:47:35","modified_gmt":"2023-11-25T08:47:35","slug":"stem-cell-mobilization-by-hyperbaric-oxygen","status":"publish","type":"post","link":"https:\/\/o2genes.com\/id\/mobilisasi-sel-induk-dengan-oksigen-hiperbarik\/","title":{"rendered":"Mobilisasi sel punca dengan oksigen hiperbarik"},"content":{"rendered":"<p>Baca kertas putih <a href=\"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00888.2005\">di sini<\/a> tentang Mobilisasi sel induk dengan oksigen hiperbarik<\/p>\n\n\n\n<p>Kami berhipotesis bahwa paparan oksigen hiperbarik (HBO2) akan memobilisasi sel induk\/progenitor<br>dari sumsum tulang dengan mekanisme yang bergantung pada oksida nitrat (NO). <strong>Populasi sel CD34 dalam sirkulasi perifer manusia berlipat ganda sebagai respons terhadap paparan tunggal 2,0 atmosfer absolut (ATA) O2 selama 2 jam. Selama 20 kali perawatan, sel CD34 yang bersirkulasi meningkat delapan kali lipat<\/strong>meskipun jumlah sel darah putih yang bersirkulasi secara keseluruhan tidak meningkat secara signifikan. Jumlah sel pembentuk koloni (CFC) meningkat dari 16 2 menjadi 26 3 CFC\/100.000 monosit yang disepuh. Peningkatan CFC sepenuhnya disebabkan oleh subpopulasi CD34, tetapi peningkatan pertumbuhan sel hanya terjadi pada sampel yang diperoleh segera setelah perawatan. Sebagian besar sel progeni mengekspresikan reseptor untuk faktor pertumbuhan endotel vaskular-2 dan faktor pertumbuhan yang diturunkan dari stroma. Pada tikus, HBO2 meningkatkan faktor sel punca yang bersirkulasi sebesar 50%, meningkatkan jumlah sel yang bersirkulasi yang mengekspresikan antigen sel punca-1 dan CD34 sebanyak 3,4 kali lipat, dan menggandakan jumlah CFC. Konsentrasi NO sumsum tulang meningkat sebesar 1.008.255 nM dalam hubungannya dengan <a href=\"https:\/\/o2genes.com\/id\/\" title=\"\">HBO2<\/a>. Mobilisasi sel punca tidak terjadi pada tikus KO yang tidak memiliki gen untuk NO sintase endotel. Selain itu, perlakuan awal tikus tipe liar dengan inhibitor NO sintase mencegah peningkatan yang diinduksi HBO2 pada faktor sel punca dan sel punca yang bersirkulasi. <strong>Kami menyimpulkan bahwa HBO2 memobilisasi sel induk\/progenitor dengan menstimulasi sintesis NO.<\/strong><\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-background wp-element-button\" href=\"https:\/\/wa.link\/iwnw8n\" style=\"background-color:#38a533\">Hubungi Kami di WhatsApp<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Read white paper here about Stem cell mobilization by hyperbaric oxygen We hypothesized that exposure to hyperbaric oxygen (HBO2) would mobilize stem\/progenitor cellsfrom the bone marrow by a nitric oxide (\u0001NO) -dependent mechanism. The population of CD34\u0001 cells in the peripheral circulation of humans doubled in response to a single exposure to 2.0 atmospheres absolute [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[132,122],"tags":[78,77,89,123],"class_list":["post-2913","post","type-post","status-publish","format-standard","hentry","category-hbot-and-stem-cells","category-oxygen-research","tag-hbot","tag-hyperbaric-oxygen","tag-hyperbaric-oxygen-therapy","tag-research"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/o2genes.com\/id\/wp-json\/wp\/v2\/posts\/2913","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/o2genes.com\/id\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/o2genes.com\/id\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/o2genes.com\/id\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/o2genes.com\/id\/wp-json\/wp\/v2\/comments?post=2913"}],"version-history":[{"count":0,"href":"https:\/\/o2genes.com\/id\/wp-json\/wp\/v2\/posts\/2913\/revisions"}],"wp:attachment":[{"href":"https:\/\/o2genes.com\/id\/wp-json\/wp\/v2\/media?parent=2913"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/o2genes.com\/id\/wp-json\/wp\/v2\/categories?post=2913"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/o2genes.com\/id\/wp-json\/wp\/v2\/tags?post=2913"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}