How Hyperbaric Oxygen Enhances Cognitive Function in Alzheimer’s and Mild Cognitive Impairment

How does Hyperbaric Oxygen Enhances Cognitive Function in Alzheimer’s and Mild Cognitive Impairment? It has been reported that environmental factors such as hypoxia could contribute to the pathogenesis of Alzheimer’s disease (AD). Therapeutics like hyperbaric oxygen treatment, which improves tissue oxygen supply and ameliorates hypoxic conditions in the brain, may be an alternative therapy for AD and amnestic mild cognitive impairment (aMCI). The present work aims to investigate the potential therapeutic effect of hyperbaric oxygen treatment for AD and aMCI.

This article explores How Hyperbaric Oxygen Enhances Cognitive Function treatment for Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI). The study involved 42 AD patients, 11 aMCI patients, and 30 control AD patients. The AD and aMCI patients received 40 minutes of hyperbaric oxygen treatment once a day for 20 days and were assessed using various neuropsychiatric assessments before and at 1-, 3-, and 6-month follow-ups after treatment.

The key findings of the study are as follows:


      1. Cognitive Improvement: One course of hyperbaric oxygen treatment significantly improved cognitive function in AD patients after 1-month follow-up, as assessed by the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). aMCI patients also showed improvements in MMSE and MoCA scores, with sustained benefits observed up to 3 months.

      1. Activities of Daily Living (ADL): ADL scores significantly improved in AD patients after 1- and 3-month follow-up, suggesting enhanced daily living abilities.

      1. Comparison with Control: Compared to control AD patients who did not receive hyperbaric oxygen treatment, the treated AD patients demonstrated significant cognitive improvement after 1-month follow-up.

      1. Brain Glucose Metabolism: Some AD and aMCI patients exhibited improved brain glucose metabolism after hyperbaric oxygen treatment, as observed through fluorodeoxyglucose positron emission tomography (FDG-P) imaging.

    The study suggests that hyperbaric oxygen treatment may offer a promising alternative therapy for AD and aMCI by temporarily improving cognitive function and daily living abilities. It also hints at potential preventive benefits for aMCI patients, possibly delaying the progression to AD. Safety concerns related to hyperbaric oxygen treatment were minimal in this study.

    However, it’s important to note that the cognitive improvements observed were temporary, with benefits diminishing over time. Further research, including studies with larger sample sizes and longer follow-up periods, will be needed to fully understand the potential and limitations of hyperbaric oxygen treatment in the context of AD and aMCI therapy.

    方法 在这项研究中,我们招募了 42 名 AD 患者、11 名 aMCI 患者和 30 名对照组 AD 患者。AD 和 aMCI 患者接受了为期 20 天、每天一次、每次 40 分钟的高压氧治疗,并在治疗前和治疗后 1 个月、3 个月和 6 个月的随访中接受了神经精神评估,包括迷你精神状态检查 (MMSE)、蒙特利尔认知评估 (MoCA) 和日常生活活动量表 (ADL)。未接受高压氧治疗的对照组 AD 患者的临床表现与接受高压氧治疗的 AD 患者相似。我们用氟脱氧葡萄糖正电子发射断层扫描检查了 10 例 AD/aMCI 患者。
    结果 在自我比较研究中,一个疗程的高压氧治疗在随访1个月后能明显改善AD患者通过MMSE和MoCA评估的认知功能;高压氧治疗还能明显改善AMCI患者随访3个月后的MMSE评分以及随访1个月和3个月后的MoCA评分。随访1个月和3个月后,AD患者的ADL量表均有明显改善。与对照组AD患者相比,接受高压氧治疗的AD患者的MMSE和MoCA在1个月随访后有明显改善。高压氧治疗还改善了部分AD和aMCI患者脑糖代谢降低的情况。

    Conclusion for How Hyperbaric Oxygen Enhances Cognitive Function

    高压氧疗法 (HBOT) has shown promise in enhancing cognitive function for individuals with Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Research suggests that oxygen under increased atmospheric pressure can boost brain oxygenation, potentially alleviating cognitive decline. HBOT’s ability to improve blood flow, reduce inflammation, and promote neurogenesis may be key in mitigating AD and MCI symptoms. Although more studies are needed to fully understand its efficacy, HBOT represents a non-invasive and innovative avenue for addressing cognitive challenges associated with these conditions, offering hope for improved quality of life and cognitive outcomes in affected individuals.doe