Hyperbaric oxygen can induce angiogenesis and recover erectile function

Cocoon and Hyperbaric oxygen for erectile dysfunction

This article explores the potential of hyperbaric oxygen therapy (HBOT) in treating non-surgical erectile dysfunction (ED). The study involved 30 men suffering from chronic ED and treated with 40 daily HBOT sessions. The results showed that HBOT significantly improved all aspects of sexual function, with a notable 88% improvement in erectile function. The treatment induced penile angiogenesis, as demonstrated by perfusion MRI, which showed a significant increase in blood flow. The study suggests that HBOT can effectively reverse the common underlying causes of ED, such as atherosclerosis and reduced penile perfusion, even in cases where traditional treatments like phosphodiesterase-5 inhibitors (PDE5Is) have failed. Further research is needed to determine the optimal protocols and patient subgroups for this therapy.

Hyperbaric oxygen can induce angiogenesis and recover erectile function

Erectile dysfunction (ED) is caused by microvascular or macrovascular insufficiency in the majority of patients. Recent studies have shown that hyperbaric oxygen therapy (HBOT) can induce angiogenesis in different body organs. The effect of HBOT on the non-surgery-related ED has not been investigated yet. The aim of the current study was to evaluate the effects of HBOT on sexual function and penile vascular bed in non-surgical ED patients. A prospective analysis of patients suffering from chronic ED treated with 40 daily HBOT sessions. Clinical efficacy was assessed using the International Index of Erectile Function questionnaire (IIEF) and a global efficacy question (GEQ). The effect on the penile vascular bed was evaluated by perfusion MRI.

Thirty men (mean age of 59.2 ± 1.4) suffering from ED for 4.2 ± 0.6 years completed the protocol. HBOT significantly improved all IIEF domains by 15–88% (p < 0.01). Erectile function improved by 88% (p < 0.0001) and 80% of the patients reported positive outcome according to the GEQ. Angiogenesis was indicated by perfusion MRI that showed a significant increase by 153.3 ± 43.2% of K-trans values in the corpus cavernous (p < 0.0001). HBOT can induce penile angiogenesis and improve erectile function in men suffering from EcD. HBOT reverses the basic common pathophysiology, atherosclerosis and decreased penile perfusion, responsible for most cases of ED.


Q1: What is hyperbaric oxygen therapy (HBOT), and how does it work in relation to angiogenesis and erectile function recovery?

A1: Hyperbaric oxygen therapy involves the inhalation of 95% oxygen at increased atmospheric pressure. It can induce angiogenesis, which is the formation of new blood vessels, in the penile area, leading to improved blood flow. This improved blood flow plays a vital role in the recovery of erectile function.

Q2: Can hyperbaric oxygen therapy effectively treat erectile dysfunction (ED), even in cases where traditional medications have failed?

A2: Research suggests that HBOT can be effective in treating ED, including cases where traditional medications like phosphodiesterase-5 inhibitors (PDE5Is) have been unsuccessful. It addresses the underlying vascular issues responsible for ED.

Q3: What is angiogenesis, and why is it significant in the context of ED treatment using HBOT?

A3: Angiogenesis is the process of developing new blood vessels. In the context of ED, it is significant because it enhances blood flow to the penis, which is crucial for achieving and maintaining erections.

Q4: How does hyperbaric oxygen therapy induce angiogenesis, and what is its role in restoring blood flow to the penile area?

A4: HBOT increases oxygen levels in body tissues and stimulates the release of factors like vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1alpha (HIF-1alpha), which promote angiogenesis. This helps repair and enhance the blood vessels in the penile region, resulting in improved blood flow and erectile function.

Q5: Is HBOT a safe and well-tolerated treatment for individuals seeking to improve their erectile function?

A5: HBOT is generally considered safe when administered by qualified medical professionals. It is well-tolerated, and most side effects, such as mild ear discomfort, are temporary and easily manageable.


Hyperbaric oxygen can induce angiogenesis and recover erectile function in men suffering from ED. HBOT reverses the basic common pathophysiology, atherosclerosis and decreased penile perfusion, responsible for most of ED cases. The treatment can be considered even years after the onset of erectile dysfunction and in men with unsatisfactory response to PDE5Is. Further studies are needed to evaluate the subgroups of men who can benefit the most from this treatment.

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